He suggested the pairing rules given in the table. This proves the concept of multiple codons for one tRNA otherwise known as wobble hypothesis. Source hereįor example, in the image above, the 5′ end base of anticodon is G which can attach with any base between U and C of 3′ end of the mRNA codon. He proposed that the first two bases in a codon form base pairs with the tRNA anticodon according to the usual rules (A-U and G-C) but that the base at the 5′ end of the anticodon is less spatially constrained than the first two and can form hydrogen bonds with more than one base at the 3′ end of the codon. To account for these observations, the wobble concept was advanced in 1966 by Francis Crick. So, there must be multiple codons that can pair with single tRNA molecule.) But later it was found that the tRNAs present in a cell are less in number. So, earlier scientists presumed that there should be 61 tRNAs for 61 codons.
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